Is The Topis Clinic the Right Polynucleotide Clinic for Me in Manchester?

The Topis Clinic in Manchester is The Aesthetic Standard’s recommended polynucleotide clinic in the city following a review of Dr Shree Topis’s credentials, safety standards and patient feedback. The Topis Clinic may be the right choice for patients who: Want polynucleotide treatment from a GMC-registered doctor with 5 years of polynucleotide experience Want an assessment-led approach with a dedicated 45-minute consultation before any treatment is agreed Have concerns about skin dehydration, early laxity or loss of skin quality Want a verified polynucleotide clinic in Manchester that has been independently checked Patients unsure whether polynucleotide is right for them are encouraged to book a consultation with Dr Shree Topis at The Topis Clinic, where suitability and the most appropriate treatment will be confirmed before any course begins. The Topis Clinic is listed on The Aesthetic Standard’s polynucleotide clinics in Manchester page as a verified provider in the city.

How Do I Book a Polynucleotide Consultation at The Topis Clinic Manchester?

Patients can book a polynucleotide consultation at The Topis Clinic in Manchester directly through www.thetopisclinic.co.uk. The Topis Clinic takes enquiries from patients across Greater Manchester and the surrounding areas. Every patient at The Topis Clinic attends a 45-minute consultation before polynucleotide treatment is agreed. Treatment takes place on a separate appointment, not on the same day as the consultation. There is no separate consultation fee for patients who proceed with a polynucleotide course at The Topis Clinic in Manchester.

Does Dr Shree Topis Offer a Consultation Before Polynucleotide at The Topis Clinic?

Yes. A dedicated 45-minute consultation with Dr Shree Topis is required before any polynucleotide treatment is agreed at The Topis Clinic in Manchester. New patients cannot have their consultation and first treatment session on the same day. The consultation at The Topis Clinic covers skin assessment, medical history, contraindication screening and realistic expectations for polynucleotide treatment. Treatment only proceeds if Dr Shree Topis judges the patient to be suitable. Full details of what to expect at the consultation are covered in the polynucleotide what to expect guide at The Topis Clinic.

Can I Have Polynucleotide at The Topis Clinic Manchester if I Am Pregnant or Breastfeeding?

No. Dr Shree Topis does not treat pregnant or breastfeeding patients with polynucleotide at The Topis Clinic in Manchester. Polynucleotide injectables have not been studied in pregnant or breastfeeding patients, and The Topis Clinic takes a precautionary approach to patient safety. Patients who are pregnant or breastfeeding are welcome to book a consultation at The Topis Clinic to plan polynucleotide treatment for after that period.

Is Polynucleotide the Same as a Dermal Filler?

No. Polynucleotide is not a dermal filler. Polynucleotide is an injectable biostimulator derived from salmon or trout DNA that works by stimulating collagen and elastin production and improving skin hydration, firmness and overall skin quality. Unlike dermal fillers, polynucleotide does not add volume or reshape facial structure. Patients at The Topis Clinic in Manchester seeking volume or structural change are assessed at consultation with Dr Shree Topis, who will advise on the most appropriate treatment for their concerns.

Are Salmon Sperm Injections the Same as Polynucleotide at The Topis Clinic Manchester?

Yes. Salmon sperm injections is a colloquial term used to describe polynucleotide treatment. The active ingredient in polynucleotide is purified DNA derived from salmon or trout, which is processed to a high standard of purity before clinical use. The treatment Dr Shree Topis performs at The Topis Clinic in Manchester is the same whether patients arrive having searched for polynucleotide, PDRN or salmon sperm injections in Manchester. Full information on the source and composition of polynucleotide is available on the salmon sperm injections guide. Any questions about the product used at The Topis Clinic can be raised with Dr Shree Topis at the initial consultation.

Does The Topis Clinic in Manchester Offer Polynucleotide Treatment Under the Eyes?

Yes. Dr Shree Topis treats the under-eye area with polynucleotide at The Topis Clinic in Manchester. Polynucleotide under eye treatment is used to address early hollowing, loss of skin quality and fine lines beneath the eye. Dr Shree Topis assesses the under-eye area at consultation before confirming whether polynucleotide is appropriate for that concern. Full information on polynucleotide under eye treatment is available on the polynucleotide under eyes guide.

Can Men Have Polynucleotide at The Topis Clinic Manchester?

Yes. Male patients at The Topis Clinic in Manchester receive the same 45-minute consultation and assessment process as all patients. Men seeking polynucleotide treatment with Dr Shree Topis typically want to address dehydration, dullness and early loss of skin quality. The expected result is a natural improvement in skin quality without added volume or structural change.

Will Polynucleotide at The Topis Clinic Work on My Neck and Décolletage?

Yes. Dr Shree Topis treats the face, neck and décolletage with polynucleotide at The Topis Clinic in Manchester. Many patients in their 40s and 50s include the neck and décolletage in their polynucleotide course to address crepey texture and dehydration in those areas. The suitability of these areas is assessed at consultation with Dr Shree Topis, and any change to the total cost is confirmed before treatment begins.

How Long Should I Wait Between Polynucleotide and Other Injectable Treatments at The Topis Clinic?

Patients planning to combine polynucleotide with other treatments are advised to discuss their full treatment plan with Dr Shree Topis at consultation. As a general guide, The Topis Clinic recommends the following: Wait at least two weeks after anti-wrinkle or dermal filler treatment before polynucleotide at The Topis Clinic Wait at least two weeks after polynucleotide before anti-wrinkle or dermal filler treatment Wait at least four weeks after microneedling, peels or laser before polynucleotide at The Topis Clinic Wait at least four weeks after polynucleotide before microneedling, peels or laser treatment Timing is tailored to each patient’s treatment history at consultation. For information on polynucleotide results, visit the polynucleotide before and after results at The Topis Clinic. For the full site-wide guide to polynucleotide results, visit the polynucleotide before and after guide.

What Happens if I Am Not Suitable for Polynucleotide at The Topis Clinic Manchester?

If Dr Shree Topis considers a patient unsuitable for polynucleotide at The Topis Clinic in Manchester, he will decline to treat, explain why at consultation and may suggest a more appropriate alternative. Patients who are not suitable for polynucleotide are not charged a consultation fee at The Topis Clinic. This assessment-led approach, in which patient safety takes priority over bookings, was a factor in The Aesthetic Standard recommending The Topis Clinic as a verified polynucleotide provider in Manchester.

How Long Should I Wait Before Having Polynucleotide Again at The Topis Clinic?

After completing the initial two-session polynucleotide course at The Topis Clinic in Manchester, Dr Shree Topis recommends a single maintenance session every 6 to 9 months. This allows the results from the initial course to develop fully before the next session is considered. Dr Shree Topis reviews the skin at each maintenance appointment at The Topis Clinic before confirming that a further polynucleotide session is appropriate. For full information on how polynucleotide results develop over time, visit the polynucleotide before and after results at The Topis Clinic. For the full site-wide guide to polynucleotide results, visit the polynucleotide before and after guide.

Polynucleotide at The Topis Clinic Manchester: Patient FAQ

This page answers the most common patient questions about polynucleotide at The Topis Clinic in Manchester, The Aesthetic Standard’s recommended polynucleotide clinic in the city. Patients searching for a polynucleotide clinic Manchester with a qualified medical practitioner will find The Topis Clinic is led by GMC-registered doctor Dr Shree Topis, who has been delivering polynucleotide treatment in Manchester since 2021. Independent patient reviews for The Topis Clinic are available on Google, where the clinic holds a 4.9-star rating. For a full guide to polynucleotide treatment including how it works, what it treats and how it differs from other injectables, visit our polynucleotide treatment guide. For questions not covered here, patients are welcome to contact The Topis Clinic directly through www.thetopisclinic.co.uk.

For the full verified clinic profile visit The Topis Clinic: Recommended Polynucleotide Clinic in Manchester. For information about the qualified practitioner answering these questions, visit About Dr Shree Topis at The Topis Clinic.

Polynucleotides at The Topis Clinic Manchester: At a Glance

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Clinic	The Topis Clinic, Altrincham, Manchester
Practitioner	Dr Shree Topis, GMC registered
Polynucleotide experience	5 years, performing since 2021
Sessions required	2 sessions, 2 to 4 weeks apart
Consultation length	45 minutes
Price from	£150 per session / £275 for two-session course
Patient rating	4.9 stars Google
Suitable during pregnancy	No
Open to men	Yes

In This Guide

Last updated: 18 October 2026

Is The Topis Clinic the Right Polynucleotide Clinic for Me in Manchester?
The Topis Clinic in Manchester is The Aesthetic Standard’s recommended polynucleotide clinic in the city following a review of Dr Shree Topis’s credentials, safety standards and patient feedback. The Topis Clinic may be the right choice for patients who:
- Want polynucleotide treatment from a GMC-registered doctor with 5 years of polynucleotide experience
- Want an assessment-led approach with a dedicated 45-minute consultation before any treatment is agreed
- Have concerns about skin dehydration, early laxity or loss of skin quality
- Want a verified polynucleotide clinic in Manchester that has been independently checked
Patients unsure whether polynucleotide is right for them are encouraged to book a consultation with Dr Shree Topis at The Topis Clinic, where suitability and the most appropriate treatment will be confirmed before any course begins.

The Topis Clinic is listed on The Aesthetic Standard’s polynucleotide clinics in Manchester page as a verified provider in the city.
How Do I Book a Polynucleotide Consultation at The Topis Clinic Manchester?

Patients can book a polynucleotide consultation at The Topis Clinic in Manchester directly through www.thetopisclinic.co.uk. The Topis Clinic takes enquiries from patients across Greater Manchester and the surrounding areas.

Every patient at The Topis Clinic attends a 45-minute consultation before polynucleotide treatment is agreed. Treatment takes place on a separate appointment, not on the same day as the consultation.

There is no separate consultation fee for patients who proceed with a polynucleotide course at The Topis Clinic in Manchester.
Does Dr Shree Topis Offer a Consultation Before Polynucleotide at The Topis Clinic?
Yes. A dedicated 45-minute consultation with Dr Shree Topis is required before any polynucleotide treatment is agreed at The Topis Clinic in Manchester. New patients cannot have their consultation and first treatment session on the same day.

The consultation at The Topis Clinic covers skin assessment, medical history, contraindication screening and realistic expectations for polynucleotide treatment. Treatment only proceeds if Dr Shree Topis judges the patient to be suitable. Full details of what to expect at the consultation are covered in the polynucleotide what to expect guide at The Topis Clinic.
Can I Have Polynucleotide at The Topis Clinic Manchester if I Am Pregnant or Breastfeeding?
No. Dr Shree Topis does not treat pregnant or breastfeeding patients with polynucleotide at The Topis Clinic in Manchester. Polynucleotide injectables have not been studied in pregnant or breastfeeding patients, and The Topis Clinic takes a precautionary approach to patient safety.

Patients who are pregnant or breastfeeding are welcome to book a consultation at The Topis Clinic to plan polynucleotide treatment for after that period.
Is Polynucleotide the Same as a Dermal Filler?
No. Polynucleotide is not a dermal filler. Polynucleotide is an injectable biostimulator derived from salmon or trout DNA that works by stimulating collagen and elastin production and improving skin hydration, firmness and overall skin quality. Unlike dermal fillers, polynucleotide does not add volume or reshape facial structure.

Patients at The Topis Clinic in Manchester seeking volume or structural change are assessed at consultation with Dr Shree Topis, who will advise on the most appropriate treatment for their concerns.
Are Salmon Sperm Injections the Same as Polynucleotide at The Topis Clinic Manchester?
Yes. Salmon sperm injections is a colloquial term used to describe polynucleotide treatment. The active ingredient in polynucleotide is purified DNA derived from salmon or trout, which is processed to a high standard of purity before clinical use. The treatment Dr Shree Topis performs at The Topis Clinic in Manchester is the same whether patients arrive having searched for polynucleotide, PDRN or salmon sperm injections in Manchester.

Full information on the source and composition of polynucleotide is available on the salmon sperm injections guide. Any questions about the product used at The Topis Clinic can be raised with Dr Shree Topis at the initial consultation.
Does The Topis Clinic in Manchester Offer Polynucleotide Treatment Under the Eyes?
Yes. Dr Shree Topis treats the under-eye area with polynucleotide at The Topis Clinic in Manchester. Polynucleotide under eye treatment is used to address early hollowing, loss of skin quality and fine lines beneath the eye. Dr Shree Topis assesses the under-eye area at consultation before confirming whether polynucleotide is appropriate for that concern.

Full information on polynucleotide under eye treatment is available on the polynucleotide under eyes guide.
Can Men Have Polynucleotide at The Topis Clinic Manchester?
Yes. Male patients at The Topis Clinic in Manchester receive the same 45-minute consultation and assessment process as all patients. Men seeking polynucleotide treatment with Dr Shree Topis typically want to address dehydration, dullness and early loss of skin quality. The expected result is a natural improvement in skin quality without added volume or structural change.
Will Polynucleotide at The Topis Clinic Work on My Neck and Décolletage?
Yes. Dr Shree Topis treats the face, neck and décolletage with polynucleotide at The Topis Clinic in Manchester. Many patients in their 40s and 50s include the neck and décolletage in their polynucleotide course to address crepey texture and dehydration in those areas. The suitability of these areas is assessed at consultation with Dr Shree Topis, and any change to the total cost is confirmed before treatment begins.
How Long Should I Wait Between Polynucleotide and Other Injectable Treatments at The Topis Clinic?
Patients planning to combine polynucleotide with other treatments are advised to discuss their full treatment plan with Dr Shree Topis at consultation. As a general guide, The Topis Clinic recommends the following:
- Wait at least two weeks after anti-wrinkle or dermal filler treatment before polynucleotide at The Topis Clinic
- Wait at least two weeks after polynucleotide before anti-wrinkle or dermal filler treatment
- Wait at least four weeks after microneedling, peels or laser before polynucleotide at The Topis Clinic
- Wait at least four weeks after polynucleotide before microneedling, peels or laser treatment
Timing is tailored to each patient’s treatment history at consultation. For information on polynucleotide results, visit the polynucleotide before and after results at The Topis Clinic.

For the full site-wide guide to polynucleotide results, visit the polynucleotide before and after guide.
What Happens if I Am Not Suitable for Polynucleotide at The Topis Clinic Manchester?
If Dr Shree Topis considers a patient unsuitable for polynucleotide at The Topis Clinic in Manchester, he will decline to treat, explain why at consultation and may suggest a more appropriate alternative. Patients who are not suitable for polynucleotide are not charged a consultation fee at The Topis Clinic.

This assessment-led approach, in which patient safety takes priority over bookings, was a factor in The Aesthetic Standard recommending The Topis Clinic as a verified polynucleotide provider in Manchester.
How Long Should I Wait Before Having Polynucleotide Again at The Topis Clinic?
After completing the initial two-session polynucleotide course at The Topis Clinic in Manchester, Dr Shree Topis recommends a single maintenance session every 6 to 9 months. This allows the results from the initial course to develop fully before the next session is considered.

Dr Shree Topis reviews the skin at each maintenance appointment at The Topis Clinic before confirming that a further polynucleotide session is appropriate. For full information on how polynucleotide results develop over time, visit the polynucleotide before and after results at The Topis Clinic.

For the full site-wide guide to polynucleotide results, visit the polynucleotide before and after guide.

What Did The Aesthetic Standard Verify About The Topis Clinic?

The Aesthetic Standard verified The Topis Clinic in Manchester before recommending Dr Shree Topis as a polynucleotide provider. The verification process for The Topis Clinic included the following checks.

✓ GMC registration — Dr Shree Topis is registered with the General Medical Council (GMC number 7632071)

✓ BCAM membership — Dr Shree Topis holds full membership of the British College of Aesthetic Medicine

✓ Professional indemnity insurance — confirmed as covering polynucleotide treatment at The Topis Clinic in Manchester

✓ CQC registration — The Topis Clinic is registered with the Care Quality Commission

✓ Save Face accreditation — Dr Shree Topis is accredited by Save Face

✓ JCCP accreditation — Dr Shree Topis is accredited by the Joint Council for Cosmetic Practitioners

✓ Patient feedback reviewed — independent reviews from patients who completed a polynucleotide course at The Topis Clinic in Manchester were reviewed before recommendation

✓ Direct practitioner interview — The Aesthetic Standard completed a direct interview with Dr Shree Topis before listing The Topis Clinic as a verified polynucleotide provider in Manchester

The full criteria used by The Aesthetic Standard to verify polynucleotide clinics are set out on the verified clinic criteria page. For patient reviews, visit The Topis Clinic on Trustpilot.

Where Is The Topis Clinic in Manchester?

The Topis Clinic is located in Altrincham, Manchester. The clinic is accessible from across Greater Manchester and the surrounding areas, with straightforward road and public transport links from Didsbury, Chorlton, Salford, Stockport and Deansgate.

Visit the clinic directly at thetopisclinic.co.uk. Follow The Topis Clinic on Instagram, Facebook and LinkedIn at @thetopisclinic.

How Do I Enquire About Polynucleotide Treatment with Dr Shree Topis at The Topis Clinic in Manchester?

Patients interested in polynucleotide treatment with Dr Shree Topis at The Topis Clinic in Manchester can make an enquiry directly through thetopisclinic.co.uk directly. Follow The Topis Clinic on Instagram, Facebook and LinkedIn for updates, patient results and clinic news.

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The Topis Clinic Polynucleotide Clinic
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