What to Expect at The Topis Clinic Manchester: Your Complete Polynucleotide Treatment Guide

 Patients can contact The Topis Clinic directly through www.thetopisclinic.co.uk. The Topis Clinic takes enquiries from patients across Greater Manchester and the surrounding areas, and The Aesthetic Standard lists The Topis Clinic on its polynucleotide clinics in Manchester page as a verified polynucleotide provider in the city.

Every patient must attend a consultation with Dr Shree Topis before polynucleotide treatment is agreed at The Topis Clinic in Manchester. No treatment is given at the enquiry or booking stage, so the consultation is always the first step for new patients at The Topis Clinic.

When getting in touch, patients are asked to outline their skin concerns and what they hope to achieve. Dr Shree Topis uses this information to prepare for the consultation and to consider whether polynucleotide is the right treatment before the appointment at The Topis Clinic in Manchester.

The polynucleotide consultation at The Topis Clinic in Manchester lasts 45 minutes and is conducted personally by Dr Shree Topis. No treatment is given at this appointment. The consultation covers the following:

• Dr Shree Topis assesses skin quality, hydration and laxity across the areas of concern
• Medical history is reviewed and contraindications to polynucleotide are screened
• Dr Shree Topis discusses the patient’s concerns and what they hope to achieve
• He explains what polynucleotide can and cannot achieve for those specific concerns
• A treatment recommendation is made based on the assessment at The Topis Clinic
• Realistic expectations are set before any polynucleotide course is agreed
• The patient has the opportunity to ask questions before committing to treatment

Dr Shree Topis will decline to treat patients he considers unsuitable for polynucleotide at The Topis Clinic in Manchester, regardless of the patient’s preference. This assessment-led approach was a factor in The Aesthetic Standard recommending The Topis Clinic as a verified polynucleotide provider in Manchester.

For further guidance on preparing for a polynucleotide consultation, visit questions to ask at your polynucleotide consultation.

Dr Shree Topis provides every patient at The Topis Clinic in Manchester with preparation guidance before their polynucleotide appointment. Following this guidance helps achieve the best treatment experience and results.

In the week before treatment

• Where medically safe, avoid blood-thinning medications such as aspirin and ibuprofen for one week before polynucleotide treatment — check with your GP before stopping any prescribed medication
• Avoid alcohol for 48 hours before your appointment at The Topis Clinic
• Avoid vitamin E supplements for one week before treatment
• Stay well hydrated in the days leading up to your polynucleotide session at The Topis Clinic in Manchester
• Avoid peels, microneedling and laser treatments for two weeks before your appointment

On the day of treatment

• Arrive at The Topis Clinic with clean, makeup-free skin
• Do not apply skincare to the treatment area on the morning of your appointment
• Eat a light meal beforehand to reduce the risk of feeling lightheaded
• Allow at least one hour for your polynucleotide appointment at The Topis Clinic in Manchester

For more on how polynucleotide works, what it treats and what results to expect, visit the polynucleotide treatment guide.

On polynucleotide treatment day at The Topis Clinic in Manchester, Dr Shree Topis takes patients through the following steps.

1. Consent and photographs

Dr Shree Topis takes clinical photographs of the treatment area before any polynucleotide is administered at The Topis Clinic. The patient completes a consent form covering medical history, current medications and agreement to proceed with treatment.

2. Topical numbing cream

Topical numbing cream is available for patients who want it at The Topis Clinic in Manchester. Most patients find polynucleotide treatment comfortable without numbing cream.

3. Treatment

Dr Shree Topis administers polynucleotide using a careful injection technique across the treatment areas. The polynucleotide session at The Topis Clinic takes 20 to 40 minutes depending on the areas being treated.

4. Immediate aftercare review

Dr Shree Topis checks the injection sites and the patient’s immediate response following polynucleotide treatment at The Topis Clinic. Small bumps at injection sites are a normal and expected response.

5. Written aftercare guide

Patients leave The Topis Clinic in Manchester with a written aftercare guide covering the 24 to 48 hours after polynucleotide treatment and what to avoid during that period.

Polynucleotide treatment is generally well tolerated at The Topis Clinic in Manchester. Dr Shree Topis uses a fine needle across the injection points, and most patients describe a brief, sharp pinch at each point, similar to other injectable treatments.

Dr Shree Topis’s careful injection technique is designed to reduce discomfort and minimise post-treatment bumpiness at The Topis Clinic. Patients at The Topis Clinic in Manchester consistently find the treatment more comfortable than they expected.

The full polynucleotide treatment takes 20 to 40 minutes from the first injection to the last, and most patients return to normal activities the same day.

The period immediately after polynucleotide treatment at The Topis Clinic in Manchester is straightforward for most patients. Dr Shree Topis provides a written aftercare guide at the end of every appointment to support patients through the first 24 to 48 hours.

Small raised bumps appear at the injection sites immediately after polynucleotide treatment at The Topis Clinic. This is a normal response and is expected following any injectable treatment.

The bumps typically settle within 24 to 48 hours. Patients may also experience mild tenderness at the injection sites during this period following polynucleotide treatment at The Topis Clinic in Manchester.

Dr Shree Topis advises patients to avoid the following after polynucleotide treatment at The Topis Clinic:

• Do not touch or rub the treated area for 6 hours after treatment
• Avoid makeup for 24 hours after polynucleotide treatment at The Topis Clinic
• Avoid strenuous exercise, saunas, steam rooms, hot baths and alcohol for 48 hours
• Avoid retinol, vitamin C and active acids for 3 to 5 days after treatment
• Avoid facial massages, peels, microneedling and laser treatments for 2 weeks
• Apply SPF daily throughout the polynucleotide course at The Topis Clinic in Manchester

For information on what polynucleotide results look like over time, visit the polynucleotide before and after guide and the polynucleotide before and after results at The Topis Clinic.

Polynucleotide treatment under the eyes at The Topis Clinic in Manchester follows the same process as treatment across the face and neck, but Dr Shree Topis uses a more precise injection technique for the under-eye area given the sensitivity of the skin in that region. Patients can expect a brief, sharp sensation at each injection point under the eye, and small bumps at the injection sites that typically resolve within 24 to 48 hours. The aftercare guidance provided by Dr Shree Topis at The Topis Clinic applies to the under-eye area as it does to all treated areas.

Most patients seeking polynucleotide under eye treatment at The Topis Clinic in Manchester are concerned with early hollowing, loss of skin quality or fine lines beneath the eye. Dr Shree Topis assesses the under-eye area at consultation before confirming whether polynucleotide is the right treatment for those concerns. Full information on polynucleotide under eye treatment is available on the polynucleotide under eyes guide.

Salmon sperm injections is a colloquial term for polynucleotide treatment. The active ingredient in polynucleotide is purified DNA derived from salmon or trout DNA, which is processed to a high standard of purity before use. Patients who have heard the treatment referred to as salmon sperm injections can expect exactly the same treatment process at The Topis Clinic in Manchester as described on this page.

Dr Shree Topis uses clinically approved polynucleotide products at The Topis Clinic in Manchester. The treatment is the same whether patients arrive having searched for polynucleotide, PDRN, or salmon sperm injections in Manchester. Any questions about the source or composition of the polynucleotide used at The Topis Clinic can be raised with Dr Shree Topis at the initial consultation.

The four-week review is a standard part of the polynucleotide course for every patient Dr Shree Topis treats at The Topis Clinic in Manchester. It is not an optional extra and is included in the price of the two-session polynucleotide course.

At the four-week review at The Topis Clinic, Dr Shree Topis carries out the following:

• Assesses how the skin responded to the first polynucleotide session at The Topis Clinic
• Compares current skin quality with the clinical photographs taken before the first session
• Checks that the patient has no adverse reactions or ongoing concerns from the first session
• Administers the second polynucleotide session at The Topis Clinic where the skin’s response is positive
• Discusses what the patient has noticed about skin hydration and radiance since the first session

The four-week review follows the same process as the first treatment session at The Topis Clinic in Manchester. The second polynucleotide session uses the same careful injection approach Dr Shree Topis used at the first appointment.

Results from the two-session polynucleotide course Dr Shree Topis administers at The Topis Clinic in Manchester develop gradually. The timeline below reflects what most patients experience following treatment with Dr Shree Topis.

• Days 2 to 3: Injection site bumps settle and skin begins to feel more hydrated
• Week 1: Skin feels noticeably more hydrated and early radiance improvement is visible
• Week 2: Most patients at The Topis Clinic notice a clear improvement in hydration and radiance
• Week 4: Dr Shree Topis carries out the four-week review and administers the second polynucleotide session
• Weeks 6 to 8: Results continue to develop, with firmness, texture and radiance at their most improved
• Month 6 to 9: Dr Shree Topis recommends a single maintenance session every 6 to 9 months to sustain polynucleotide results

For more detail on results by age group and patient profile, visit the polynucleotide before and after results at The Topis Clinic. For the full site-wide guide to polynucleotide results, visit the polynucleotide before and after guide.

The Aesthetic Standard verified The Topis Clinic in Manchester before recommending Dr Shree Topis as a polynucleotide provider. The verification process for The Topis Clinic included the following checks.

✓ GMC registration — Dr Shree Topis is registered with the General Medical Council (GMC number 7632071)

✓ BCAM membership — Dr Shree Topis holds full membership of the British College of Aesthetic Medicine

✓ Professional indemnity insurance — confirmed as covering polynucleotide treatment at The Topis Clinic in Manchester

✓ CQC registration — The Topis Clinic is registered with the Care Quality Commission

✓ Save Face accreditation — Dr Shree Topis is accredited by Save Face

✓ JCCP accreditation — Dr Shree Topis is accredited by the Joint Council for Cosmetic Practitioners

✓ Patient feedback reviewed — independent reviews from patients who completed a polynucleotide course at The Topis Clinic in Manchester were reviewed before recommendation

✓ Direct practitioner interview — The Aesthetic Standard completed a direct interview with Dr Shree Topis before listing The Topis Clinic as a verified polynucleotide provider in Manchester

The full criteria used by The Aesthetic Standard to verify polynucleotide clinics are set out on the verified clinic criteria page.  For patient reviews, visit The Topis Clinic on Trustpilot.

The Topis Clinic is located in Altrincham, Manchester. The clinic is accessible from across Greater Manchester and the surrounding areas, with straightforward road and public transport links from Didsbury, Chorlton, Salford, Stockport and Deansgate.

Visit the clinic directly at thetopisclinic.co.uk. Follow The Topis Clinic on Instagram, Facebook and LinkedIn at @thetopisclinic. 

Patients interested in polynucleotide treatment with Dr Shree Topis at The Topis Clinic in Manchester can make an enquiry directly through thetopisclinic.co.uk directly. Follow The Topis Clinic on Instagram, Facebook and LinkedIn for updates, patient results and clinic news.

For more patient questions about Dr Shree Topis and The Topis Clinic, visit the polynucleotide FAQ at The Topis Clinic.