The Topis Clinic 
Polynucleotide Clinic in Manchester

Verified & Recommended
by The Aesthetic Standard

A 2025 study published in Journal of Skin and Stem Cell found that polydeoxyribonucleotide, the active ingredient in polynucleotide injections, activates the skin’s own repair pathways and measurably improves hydration, elasticity and overall skin quality.

Polynucleotide is not a filler. The Topis Clinic delivers polynucleotide injections in Manchester to improve skin quality from within, not to add volume or alter facial structure. Polynucleotide at The Topis Clinic activates the skin’s own fibroblasts to stimulate collagen and elastin production and hyaluronic acid from within the dermis, producing results that look healthier rather than altered.

Deep skin hydration. Polynucleotide treatment at The Topis Clinic in Manchester stimulates the skin’s own production of hyaluronic acid at a cellular level, improving hydration from within rather than simply adding moisture on the surface. Patients treated by Dr Shree Topis in Manchester often notice an improvement in skin texture and hydration from the first session, with continued development over three to six months.

Collagen and elastin stimulation. Polynucleotide injections at The Topis Clinic in Manchester activate fibroblasts in the dermis, stimulating the skin’s natural production of collagen and elastin. Dr Shree Topis advises patients at The Topis Clinic that visible skin quality improvement develops over three to six months following the course, as the skin’s regenerative processes continue to build.

Minimal downtime. Polynucleotide sessions at The Topis Clinic in Manchester take 20 to 40 minutes. Mild swelling, redness and raised marks at the injection sites are common and typically resolve within 24 to 48 hours. Bruising occurs in around 15 percent of patients and resolves within 48 to 72 hours. Most patients treated by Dr Shree Topis at The Topis Clinic return to normal activities the same day.

Natural-looking results. Polynucleotide treatment at The Topis Clinic in Manchester produces results that look healthier and more rested, not altered. Dr Shree Topis’s approach to polynucleotide injections in Manchester is designed to restore skin quality rather than change a patient’s features, and results are visible from three to six weeks following treatment.

Treatment type: Polynucleotide injections

Active ingredient: Purified polynucleotide derived from salmon or trout DNA

Common concerns treated: Skin laxity, dehydration, fine lines, crepey texture, dull skin, dark circles related to skin quality, under-eye hollows

Procedure length: 20 to 40 minutes

Injection technique: Careful micro-injection technique, allowing the product to settle at each injection point

Anaesthetic: Topical numbing cream, applied 20 to 30 minutes before treatment

Recovery time: 4 to 48 hours (mild swelling and redness). Bruising possible in around 15% of patients, resolving in 48 to 72 hours

Results visible: 3 to 6 weeks

How long results last: 6 to 12 months with maintenance every 6 to 9 months

The Aesthetic Standard assessed The Topis Clinic against its full set of verification criteria before recommending The Topis Clinic as Manchester’s verified polynucleotide clinic. Dr Shree Topis holds current GMC registration (number 7632071) and full BCAM membership and has delivered polynucleotide injections in Manchester for five years. Manchester’s aesthetics market includes practitioners with a wide range of qualifications and experience levels. Dr Shree Topis’s sustained GMC-registered practice, nine-year polynucleotide speciality and consistent 4.9-star Google review score placed The Topis Clinic in the category The Aesthetic Standard considers appropriate for a verified listing.

The Topis Clinic operates in Altrincham, Manchester, which is accessible from across Greater Manchester and the surrounding areas, including Didsbury, Chorlton, Salford, Stockport and Deansgate. Manchester’s polynucleotide market ranges from premium medically governed practices to clinics whose pricing raises questions about product quality and practitioner qualifications. The Topis Clinic sits firmly in the medically governed, doctor-led tier. The Topis Clinic’s CQC registration, Save Face accreditation and JCCP registration are each independently verifiable and were each confirmed before The Aesthetic Standard published this recommendation.

Dr Shree Topis leads polynucleotide treatment at The Topis Clinic in Manchester. Dr Shree Topis holds GMC registration number 7632071, full membership of the British College of Aesthetic Medicine and five years of experience specialising in polynucleotide injections and skin quality treatments in Manchester.

Dr Shree Topis takes a structured, assessment-led approach to polynucleotide treatment at The Topis Clinic in Manchester. Every patient at The Topis Clinic receives a full skin assessment before treatment is agreed, covering skin laxity, hydration levels, the under-eye area and the patient’s specific concerns. Dr Shree Topis then determines which treatment areas are appropriate, what course structure suits the patient’s skin, and whether any contraindications need to be considered before the first session proceeds. Dr Shree Topis delivers polynucleotide injections at The Topis Clinic using a micro-injection technique with a careful, methodical technique for more precise product placement across the face, neck and under-eye area.

Full details of Dr Shree Topis’s training, CPD activity and published contributions are available on the Dr Shree Topis polynucleotide practitioner page at The Topis Clinic.

Yes. Salmon sperm injections and polynucleotide injections are the same treatment. The Topis Clinic in Manchester delivers polynucleotide injections using purified DNA derived from salmon or trout. The informal name salmon sperm injections refers to this same ingredient and the same treatment. Dr Shree Topis uses the clinical term polynucleotide at The Topis Clinic in Manchester, but patients searching for salmon sperm injections in Manchester are looking for exactly the treatment The Topis Clinic provides.

The polynucleotide product used at The Topis Clinic in Manchester contains no salmon sperm cells, proteins or other biological matter. The DNA is purified until no cellular material remains. Fish or seafood allergy is a contraindication to polynucleotide treatment at The Topis Clinic in Manchester and must be disclosed at the consultation with Dr Shree Topis before treatment proceeds. Polynucleotide treatment is also not suitable for vegetarians or vegans. Patients can read The Aesthetic Standard’s full guide to salmon sperm injections for a detailed breakdown of the ingredient, the purification process and who is suitable for treatment.

Yes. The Topis Clinic in Manchester offers polynucleotide injections under the eyes as part of Dr Shree Topis’s treatment planning for patients with under-eye hollows, dark circles associated with skin thinning and fine lines in the under-eye area. Polynucleotides work well under the eyes because the product improves skin quality rather than adding volume, making it appropriate for patients whose concerns relate to skin texture and thinning rather than significant volume loss. Patients with significant under-eye volume loss may be better suited to tear trough filler, which Dr Shree Topis will discuss at the consultation at The Topis Clinic in Manchester.

Dr Shree Topis assesses the under-eye area individually at the initial consultation at The Topis Clinic in Manchester before any treatment is agreed. Not every patient is suitable for polynucleotide under the eyes at the first session, and Dr Shree Topis does not combine under-eye polynucleotide with certain other injectables at the same appointment. Suitability is confirmed at the consultation before treatment proceeds. Patients who want to understand what polynucleotide under the eyes involves can read The Aesthetic Standard’s polynucleotides under eyes guide before attending The Topis Clinic in Manchester.

The Topis Clinic takes a medical-first approach to polynucleotide treatment in Manchester. Dr Shree Topis assesses each patient’s skin quality, hydration levels, laxity and under-eye concerns before any treatment is agreed. Dr Shree Topis will only proceed with polynucleotide at The Topis Clinic where polynucleotide is the most appropriate treatment for that patient’s skin. Where Dr Shree Topis considers a different approach more suitable, The Topis Clinic discusses this with the patient at the consultation before any treatment is booked.

Every polynucleotide course at The Topis Clinic in Manchester begins with a dedicated 45-minute consultation with Dr Shree Topis. The Topis Clinic uses this consultation to review the patient’s medical history, screen for contraindications including fish or seafood allergy, suitability for vegan patients and blood-thinning medication, map the treatment areas, discuss realistic outcomes and answer questions before any commitment is made. No polynucleotide treatment proceeds at The Topis Clinic in Manchester without a prior consultation with Dr Shree Topis.

Dr Shree Topis delivers polynucleotide injections at The Topis Clinic in Manchester using a micro-injection technique in which the product is introduced with a careful, methodical technique. Dr Shree Topis allows the polynucleotide product to settle at each injection point before withdrawing the needle. This approach allows more precise placement, which Dr Shree Topis considers particularly important when treating the under-eye area and the neck. The most common side effects of polynucleotide treatment at The Topis Clinic are mild swelling, redness and raised marks at injection sites, which typically resolve within 24 to 48 hours. Bruising occurs in around 15 percent of patients and resolves within 48 to 72 hours. Dr Shree Topis discusses all potential side effects with every patient at The Topis Clinic Manchester consultation before treatment begins.

After each polynucleotide session at The Topis Clinic in Manchester, Dr Shree Topis provides a written aftercare guide covering the days following treatment. Patients at The Topis Clinic are advised to avoid touching the treated area and wearing makeup for 24 hours, avoid alcohol for 24 hours before and after treatment, and avoid intense exercise, saunas and heat for 24 to 48 hours following each session. Patients are also advised to use high-SPF sunscreen consistently throughout the course.

Patients who want a full step-by-step walkthrough of what polynucleotide treatment involves at The Topis Clinic in Manchester can read The Topis Clinic polynucleotide what to expect guide.

Polynucleotide results at The Topis Clinic in Manchester develop gradually following the two-session course. Most patients treated by Dr Shree Topis notice visible improvement in skin quality from three to six weeks following treatment. Results continue to develop over three to six months as the skin’s collagen and elastin stimulation progresses. The Topis Clinic schedules a review after the course is complete to assess each patient’s response and discuss maintenance.

The Topis Clinic treats patients seeking polynucleotide for a range of skin concerns including laxity, dehydration, fine lines, crepey texture, dull skin and under-eye hollows. Dr Shree Topis in Manchester tailors the injection pattern at each session to the patient’s specific skin concerns and response to previous treatment. The Topis Clinic does not apply a fixed protocol to every patient.

Two representative patient scenarios from The Topis Clinic in Manchester are set out below. Both scenarios are illustrative. Individual results vary.

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Individual results from polynucleotide treatment at The Topis Clinic in Manchester vary with age, skin condition and lifestyle. The Aesthetic Standard’s polynucleotide before and after guide for Manchester and The Topis Clinic polynucleotide before and after page contain further case detail and outcome information.

The Topis Clinic charges from £150 per polynucleotide session in Manchester. A full two-session course at The Topis Clinic starts from £275. The Topis Clinic includes the initial 45-minute consultation with Dr Shree Topis and a review appointment in the course price. There is no separate consultation fee at The Topis Clinic in Manchester when polynucleotide treatment is booked.

Dr Shree Topis recommends a maintenance polynucleotide session every six to nine months at The Topis Clinic in Manchester to sustain the results of the course. The Topis Clinic confirms the full cost of polynucleotide treatment, including any maintenance schedule, at the consultation with Dr Shree Topis before any treatment is agreed. No deposit is required at the consultation.

The Topis Clinic’s polynucleotide pricing in Manchester is confirmed at the consultation and is published here as supplied by The Topis Clinic. Patients should confirm the current price directly with The Topis Clinic before booking. For a full breakdown of what the polynucleotide consultation and treatment process involves at The Topis Clinic, read The Topis Clinic polynucleotide what to expect guide and The Aesthetic Standard’s Manchester polynucleotide clinic guide.

The Topis Clinic completed The Aesthetic Standard’s full verification process before being listed as the recommended polynucleotide clinic in Manchester. The Aesthetic Standard’s editorial team reviewed each of the following items independently before The Topis Clinic was published on this site.

✓ GMC registration confirmed. Dr Shree Topis, GMC number 7632071, verified on the GMC Medical Register

✓ BCAM membership confirmed. Full member of the British College of Aesthetic Medicine

✓ Professional indemnity insurance confirmed, covering polynucleotide treatment specifically

✓ CQC registration: Yes. Verified on the Care Quality Commission register

✓ Save Face accreditation: Yes. Verified on Save Face

✓ JCCP accreditation: Yes. Verified on the Joint Council for Cosmetic Practitioners register

✓ Independent patient feedback reviewed. Google review score: 4.9 stars

✓ Direct practitioner interview conducted by The Aesthetic Standard editorial team with Dr Shree Topis

For the full criteria we apply to every clinic, visit our verified clinic page. For patient reviews, visit The Topis Clinic on Trustpilot.

The Topis Clinic is located in Altrincham, Manchester, making polynucleotide treatment with Dr Shree Topis accessible from across Greater Manchester and the surrounding areas. Patients travel to The Topis Clinic in Manchester from Didsbury, Chorlton, Salford, Stockport and Deansgate for polynucleotide injections with Dr Shree Topis. The Topis Clinic is served by Manchester’s central rail and bus network, with parking available nearby.

Patients can find directions, confirm opening hours and check availability at The Topis Clinic in Manchester by visiting www.thetopisclinic.co.uk. Patients can also follow The Topis Clinic on Instagram, Facebook  and Linkedin at @thetopisclinic for clinic updates and polynucleotide treatment information.

Patients wanting to enquire about polynucleotide treatment at The Topis Clinic in Manchester can contact The Topis Clinic directly through www.thetopisclinic.co.uk. The Topis Clinic in Manchester books all polynucleotide consultations with Dr Shree Topis through its own website.

Patients can also follow @thetopisclinic on Instagram, Facebook and Linkedin for clinic updates, patient results and polynucleotide treatment information from Dr Shree Topis in Manchester.

For more questions about polynucleotide at The Topis Clinic Manchester visit our full FAQ page.